Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model

• Main Authors: Maria Savyuk (Author), Mikhail Krivonosov (Author), Tatiana Mishchenko (Author), Irina Gazaryan (Author), Mikhail Ivanchenko (Author), Anna Khristichenko (Author), Andrey Poloznikov (Author), Dmitry Hushpulian (Author), Sergey Nikulin (Author), Evgeny Tonevitsky (Author), Guzal Abuzarova (Author), Elena Mitroshina (Author), Maria Vedunova (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel potent analog of the branched tail oxyquinoline group of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, neuradapt, has been studied in two treatment regimes in an in vitro hypoxia model on murine primary hippocampal cultures. Neuradapt activates the expression of HIF1 and HIF2...