Involvement of methylation of MicroRNA-122, −125b and -106b in regulation of Cyclin G1, CAT-1 and STAT3 target genes in isoniazid-induced liver injury

• Main Authors: Yuhong Li (Author), Qi Ren (Author), Lingyan Zhu (Author), Yingshu Li (Author), Jinfeng Li (Author), Yiyang Zhang (Author), Guoying Zheng (Author), Tiesheng Han (Author), Shufeng Sun (Author), Fumin Feng (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background This investigation aimed to evaluate the role of methylation in the regulation of microRNA (miR)-122, miR-125b and miR-106b gene expression and the expression of their target genes during isoniazid (INH)-induced liver injury. Methods Rats were given INH 50 mg kg− 1·d− 1 once per...