Chili pepper extracts, capsaicin, and dihydrocapsaicin as potential anticancer agents targeting topoisomerases

• Main Authors: Terézia Hudáková (Author), Martina Šemeláková (Author), Peter Očenáš (Author), Mária Kožurková (Author), Kristína Krochtová (Author), Simona Sovová (Author), Zuzana Tóthová (Author), Zuzana Guľášová (Author), Peter Popelka (Author), Peter Solár (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts...