ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming through EphB2-MNK-eIF4E signaling in both mice and humans

• Main Authors: Eric T. David (Author), Muhammad Saad Yousuf (Author), Hao-Ruei Mei (Author), Ashita Jain (Author), Sharada Krishnagiri (Author), Hajira Elahi (Author), Rupali Venkatesan (Author), Kolluru D. Srikanth (Author), Gregory Dussor (Author), Matthew B. Dalva (Author), Theodore J. Price (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ephrin-B-EphB signaling can promote pain through ligand-receptor interactions between peripheral cells, like immune cells expressing ephrin-Bs, and EphB receptors expressed by DRG neurons. Previous studies have shown increased ephrin-B2 expression in peripheral tissues like synovium of rheumatoid an...