Warfarin Anticoagulation Therapy in Caribbean Hispanics of Puerto Rico: A Candidate Gene Association Study

• Main Authors: Karla Claudio-Campos (Author), Aurora Labastida (Author), Alga Ramos (Author), Andrea Gaedigk (Author), Jessicca Renta-Torres (Author), Dariana Padilla (Author), Giselle Rivera-Miranda (Author), Stuart A. Scott (Author), Gualberto Ruaño (Author), Carmen L. Cadilla (Author), Jorge Duconge-Soler (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Existing algorithms account for ~50% of observed variance in warfarin dose requirements after including common polymorphisms. However, they do not perform as well in populations other than Caucasians, in part because some ethno-specific genetic variants are overlooked. The objective of the present s...