Garcinol Attenuates Lipoprotein(a)-Induced Oxidative Stress and Inflammatory Cytokine Production in Ventricular Cardiomyocyte through α7-Nicotinic Acetylcholine Receptor-Mediated Inhibition of the p38 MAPK and NF-κB Signaling Pathways

• Main Authors: Nen-Chung Chang (Author), Chi-Tai Yeh (Author), Yen-Kuang Lin (Author), Kuang-Tai Kuo (Author), Iat-Hang Fong (Author), Nicholas G. Kounis (Author), Patrick Hu (Author), Ming-Yow Hung (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Garcinol, a nicotinic acetylcholine receptor (nAChR) antagonist, has recently been established as an anti-inflammation agent. However, the molecular mechanism by which garcinol suppresses inflammation in the context of acute myocardial infarction (AMI) remains unclear. <b>Hypothesis:</b>...