Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of <i>SHP-1</i> and Inhibition of JAK/STAT Signaling Pathway

• Главные авторы: Futoon Abedrabbu Al-Rawashde (Автор), Ola M. Al-Sanabra (Автор), Moath Alqaraleh (Автор), Ahmad Q. Jaradat (Автор), Abdullah Saleh Al-Wajeeh (Автор), Muhammad Farid Johan (Автор), Wan Rohani Wan Taib (Автор), Imilia Ismail (Автор), Hamid Ali Nagi Al-Jamal (Автор)
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• Опубликовано: MDPI AG, 2023-06-01T00:00:00Z.
• Предметы: article
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The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of chronic myeloid leukemia (CML). <i>SHP-1</i> functions as a TSG and negatively regulates JAK/STAT signaling. Enhancement of <i>SHP-1</i> expression by demethylation provides molecular...