Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of <i>SHP-1</i> and Inhibition of JAK/STAT Signaling Pathway

• Main Authors: Futoon Abedrabbu Al-Rawashde (Author), Ola M. Al-Sanabra (Author), Moath Alqaraleh (Author), Ahmad Q. Jaradat (Author), Abdullah Saleh Al-Wajeeh (Author), Muhammad Farid Johan (Author), Wan Rohani Wan Taib (Author), Imilia Ismail (Author), Hamid Ali Nagi Al-Jamal (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of chronic myeloid leukemia (CML). <i>SHP-1</i> functions as a TSG and negatively regulates JAK/STAT signaling. Enhancement of <i>SHP-1</i> expression by demethylation provides molecular...