Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of <i>SHP-1</i> and Inhibition of JAK/STAT Signaling Pathway

• Hoofdauteurs: Futoon Abedrabbu Al-Rawashde (Auteur), Ola M. Al-Sanabra (Auteur), Moath Alqaraleh (Auteur), Ahmad Q. Jaradat (Auteur), Abdullah Saleh Al-Wajeeh (Auteur), Muhammad Farid Johan (Auteur), Wan Rohani Wan Taib (Auteur), Imilia Ismail (Auteur), Hamid Ali Nagi Al-Jamal (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The epigenetic silencing of tumor suppressor genes (TSGs) is critical in the development of chronic myeloid leukemia (CML). <i>SHP-1</i> functions as a TSG and negatively regulates JAK/STAT signaling. Enhancement of <i>SHP-1</i> expression by demethylation provides molecular...