PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids

• Main Authors: Daniel Oropeza (Author), Nathalie Jouvet (Author), Khalil Bouyakdan (Author), Gabrielle Perron (Author), Lea-Jeanne Ringuette (Author), Louis H. Philipson (Author), Robert S. Kiss (Author), Vincent Poitout (Author), Thierry Alquier (Author), Jennifer L. Estall (Author)
• Format: Book
• Published: Elsevier, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important for nutrient metabolism. Islets of type 2 diabetic subjects have reduced PGC-1α expression and this is associated with decreased insulin secretion, ye...