Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice

• Main Authors: Haoyang Wang (Author), Kohji Fukunaga (Author), An Cheng (Author), Yifei Wang (Author), Nariko Arimura (Author), Hiroshi Yoshino (Author), Takuya Sasaki (Author), Ichiro Kawahata (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is characterized by dopaminergic (DAergic) neuronal loss in the substantia nigra pars compacta (SNpc), resulting from α-synuclein (αSyn) toxicity. We previously reported that αSyn oligomerization and toxicity are regulated by the fatty-acid binding protein 3 (FABP3), an...