Differentially Tolerized Mouse Antigen Presenting Cells Share a Common miRNA Signature Including Enhanced mmu-miR-223-3p Expression Which Is Sufficient to Imprint a Protolerogenic State

• Main Authors: Matthias Bros (Author), Mahmoud Youns (Author), Verena Kollek (Author), Diana Buchmüller (Author), Franziska Bollmann (Author), Ean-Jeong Seo (Author), Jonathan Schupp (Author), Evelyn Montermann (Author), Svetlana Usanova (Author), Hartmut Kleinert (Author), Thomas Efferth (Author), Angelika B. Reske-Kunz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dendritic cells (DCs) are pivotal for the induction and maintenance of antigen-specific tolerance and immunity. miRNAs mediate post-transcriptional gene regulation and control in part the differentiation and stimulation-induced immunogenic function of DCs. However, the relevance of miRNAs for the in...