Disorder of three‐dimensional chromosome structure plays a role in carcinogenesis

• Main Authors: Linlin Zhang (Author), Fangming Liu (Author), Lihong Wu (Author), Suolan Fu (Author), Leilei Xing (Author), Lianghui Zhang (Author), Xiangdong Wang (Author), Yong‐Xiao Wang (Author)
• Format: Book
• Published: Wiley, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The three‐dimensional structure of chromatin is an essential part of gene expression and regulation. Modules far apart in the one‐dimensional DNA sequence can be close to each other in 3D and activated by spatially folding. Normal gene activation requires such long‐distance interactions. Ho...