Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells

• Principais autores: Chen Guo (Autor), Qiuju Ran (Autor), Chun Sun (Autor), Tingting Zhou (Autor), Xi Yang (Autor), Jizhou Zhang (Autor), Shifeng Pang (Autor), Yechen Xiao (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Chemotherapeutic patients with leukemia often relapse and produce drug resistance due to the existence of leukemia stem cells (LSCs). Fibroblast growth factor receptor 3 (FGFR3) signaling mediates the drug resistance of LSCs in chronic myeloid leukemia (CML). However, the function of FGFR3 in acute...