Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells

• 主要な著者: Chen Guo (著者), Qiuju Ran (著者), Chun Sun (著者), Tingting Zhou (著者), Xi Yang (著者), Jizhou Zhang (著者), Shifeng Pang (著者), Yechen Xiao (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Chemotherapeutic patients with leukemia often relapse and produce drug resistance due to the existence of leukemia stem cells (LSCs). Fibroblast growth factor receptor 3 (FGFR3) signaling mediates the drug resistance of LSCs in chronic myeloid leukemia (CML). However, the function of FGFR3 in acute...