Host-directed therapy with 2-deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2

• Main Authors: Laxmikant Wali (Author), Michael Karbiener (Author), Scharon Chou (Author), Vitalii Kovtunyk (Author), Adam Adonyi (Author), Irene Gösler (Author), Ximena Contreras (Author), Delyana Stoeva (Author), Dieter Blaas (Author), Johannes Stöckl (Author), Thomas R. Kreil (Author), Guido A. Gualdoni (Author), Anna-Dorothea Gorki (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rhinoviruses (RVs) and coronaviruses (CoVs) upregulate host cell metabolic pathways such as glycolysis to meet their bioenergetic demands for rapid multiplication. Using the glycolysis inhibitor 2-deoxy-d-glucose (2-DG), we assessed the dose-dependent inhibition of viral replication of minor- and ma...