Host-directed therapy with 2-deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2

• المؤلفون الرئيسيون: Laxmikant Wali (مؤلف), Michael Karbiener (مؤلف), Scharon Chou (مؤلف), Vitalii Kovtunyk (مؤلف), Adam Adonyi (مؤلف), Irene Gösler (مؤلف), Ximena Contreras (مؤلف), Delyana Stoeva (مؤلف), Dieter Blaas (مؤلف), Johannes Stöckl (مؤلف), Thomas R. Kreil (مؤلف), Guido A. Gualdoni (مؤلف), Anna-Dorothea Gorki (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Rhinoviruses (RVs) and coronaviruses (CoVs) upregulate host cell metabolic pathways such as glycolysis to meet their bioenergetic demands for rapid multiplication. Using the glycolysis inhibitor 2-deoxy-d-glucose (2-DG), we assessed the dose-dependent inhibition of viral replication of minor- and ma...