Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo

• Main Authors: Hassan Javanbakht (Author), Henrik Mueller (Author), Johanna Walther (Author), Xue Zhou (Author), Anaïs Lopez (Author), Thushara Pattupara (Author), Julie Blaising (Author), Lykke Pedersen (Author), Nanna Albæk (Author), Malene Jackerott (Author), Tianlai Shi (Author), Corinne Ploix (Author), Wouter Driessen (Author), Robert Persson (Author), Jacob Ravn (Author), John A.T. Young (Author), Søren Ottosen (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-of-care therapies only rarely lead to a functional cure, defined as durable hepatitis B surface antigen (HBsAg) loss following treatment. The goal for next generation CHB therapies is to achieve a higher rate...