Using In Silico Molecular Docking to Explain Differences in Receptor Binding Behavior of HHC and THCV Isomers: Revealing New Binding Modes

• Главные авторы: Mehdi Haghdoost (Автор), Yossef López de los Santos (Автор), Megan Brunstetter (Автор), Morgan L. Ferretti (Автор), Matthew Roberts (Автор), Marcel O. Bonn-Miller (Автор)
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• Опубликовано: MDPI AG, 2024-05-01T00:00:00Z.
• Предметы: article
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Even slight structural differences between phytocannabinoid isomers are usually enough to cause a change in their biological properties. In this study, we used in vitro CB1 agonism/antagonism assays to compare the receptor binding functionality of THCV (tetrahydrocannabivarin) and HHC (hexahydrocann...