Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy

• 主要な著者: Hossameldin Abouhish (著者), Menaka C. Thounaojam (著者), Ravirajsinh N. Jadeja (著者), Diana R. Gutsaeva (著者), Folami L. Powell (著者), Mohamed Khriza (著者), Pamela M. Martin (著者), Manuela Bartoli (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We investigated the contributing role of the histone deacetylase 6 (HDAC6) to the early stages of diabetic retinopathy (DR). Furthermore, we examined the mechanism of action of HDAC6 in human retinal endothelial cells (HuREC) exposed to glucidic stress. Streptozotocin-induced diabetic rats (STZ-rats...