Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework

Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework

<b>Background/Objectives:</b> Plasma levels of 4β-hydroxycholesterol (4β-OHC), a CYP3A-specific metabolite of cholesterol, are elevated after administration of CYP3A inducers like rifampicin and carbamazepine. To simulate such plasma 4β-OHC increase, we developed a physiologically based...

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Main Authors: Aneesh V. Karkhanis (Author), Matthew D. Harwood (Author), Felix Stader (Author), Frederic Y. Bois (Author), Sibylle Neuhoff (Author)
Format: Book
Published: MDPI AG, 2024-09-01T00:00:00Z.
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