A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels

• Main Authors: Alejandro Valdés-Jiménez (Author), Daniel Jiménez-González (Author), Aytug K. Kiper (Author), Susanne Rinné (Author), Niels Decher (Author), Wendy González (Author), Miguel Reyes-Parada (Author), Gabriel Núñez-Vivanco (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. Also, it would be a reasonable first step for the design of novel multitarget compounds. Most of the current com...