A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels

• Главные авторы: Alejandro Valdés-Jiménez (Автор), Daniel Jiménez-González (Автор), Aytug K. Kiper (Автор), Susanne Rinné (Автор), Niels Decher (Автор), Wendy González (Автор), Miguel Reyes-Parada (Автор), Gabriel Núñez-Vivanco (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Предметы: article
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The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. Also, it would be a reasonable first step for the design of novel multitarget compounds. Most of the current com...