Design, synthesis, and evaluation of curcumin analogues as potential inhibitors of bacterial sialidase

• Main Authors: Bo Ram Kim (Author), Ji-Young Park (Author), Hyung Jae Jeong (Author), Hyung-Jun Kwon (Author), Su-Jin Park (Author), In-Chul Lee (Author), Young Bae Ryu (Author), Woo Song Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sialidases are key virulence factors that remove sialic acid from the host cell surface glycan, unmasking receptors that facilitate bacterial adherence and colonisation. In this study, we developed potential agents for treating bacterial infections caused by Streptococcus pneumoniae Nan A that inhib...