<i>Trypanosoma cruzi</i> Sirtuin 2 as a Relevant Druggable Target: New Inhibitors Developed by Computer-Aided Drug Design

• Main Authors: Glaucio Monteiro Ferreira (Author), Thales Kronenberger (Author), Vinicius Gonçalves Maltarollo (Author), Antti Poso (Author), Fernando de Moura Gatti (Author), Vitor Medeiros Almeida (Author), Sandro Roberto Marana (Author), Carla Duque Lopes (Author), Daiane Yukie Tezuka (Author), Sérgio de Albuquerque (Author), Flavio da Silva Emery (Author), Gustavo Henrique Goulart Trossini (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Trypanosoma cruzi</i>, the etiological agent of Chagas disease, relies on finely coordinated epigenetic regulation during the transition between hosts. Herein we targeted the silent information regulator 2 (Sir2) enzyme, a NAD⁺-dependent class III histone deacet...