PCR-based techniques for leprosy diagnosis: from the laboratory to the clinic.

• Main Authors: Alejandra Nóbrega Martinez (Author), Carolina Talhari (Author), Milton Ozório Moraes (Author), Sinésio Talhari (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In leprosy, classic diagnostic tools based on bacillary counts and histopathology have been facing hurdles, especially in distinguishing latent infection from active disease and diagnosing paucibacillary clinical forms. Serological tests and IFN-gamma releasing assays (IGRA) that employ humoral and...