Gene and Protein Expression Is Altered by Ascorbate Availability in Murine Macrophages Cultured under Tumour-Like Conditions

• Glavni autori: Abel D. Ang (Autor), Margreet C. M. Vissers (Autor), Eleanor R. Burgess (Autor), Margaret J. Currie (Autor), Gabi U. Dachs (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-03-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Tumour-associated macrophages (TAMs) are ubiquitously present in tumours and commonly associated with poor prognosis. In immune cells, ascorbate affects epigenetic regulation, differentiation and phenotype via its co-factor activity for the 2-oxoglutarate dependent dioxygenase enzymes. Here, we dete...