Gene and Protein Expression Is Altered by Ascorbate Availability in Murine Macrophages Cultured under Tumour-Like Conditions

• Hauptverfasser: Abel D. Ang (Verfasst von), Margreet C. M. Vissers (Verfasst von), Eleanor R. Burgess (Verfasst von), Margaret J. Currie (Verfasst von), Gabi U. Dachs (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2021-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Tumour-associated macrophages (TAMs) are ubiquitously present in tumours and commonly associated with poor prognosis. In immune cells, ascorbate affects epigenetic regulation, differentiation and phenotype via its co-factor activity for the 2-oxoglutarate dependent dioxygenase enzymes. Here, we dete...