Gene and Protein Expression Is Altered by Ascorbate Availability in Murine Macrophages Cultured under Tumour-Like Conditions

• मुख्य लेखकों: Abel D. Ang (लेखक), Margreet C. M. Vissers (लेखक), Eleanor R. Burgess (लेखक), Margaret J. Currie (लेखक), Gabi U. Dachs (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Tumour-associated macrophages (TAMs) are ubiquitously present in tumours and commonly associated with poor prognosis. In immune cells, ascorbate affects epigenetic regulation, differentiation and phenotype via its co-factor activity for the 2-oxoglutarate dependent dioxygenase enzymes. Here, we dete...