Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice

• Main Authors: Charles J. Billington (Author), Brian Schmidt (Author), Ralph S. Marcucio (Author), Benedikt Hallgrimsson (Author), Rajaram Gopalakrishnan (Author), Anna Petryk (Author)
• Format: Book
• Published: The Company of Biologists, 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Holoprosencephaly (HPE) is a developmental anomaly characterized by inadequate or absent midline division of the embryonic forebrain and midline facial defects. It is believed that interactions between genes and the environment play a role in the widely variable penetrance and expressivity of HPE, a...