Novel Pan-Pim Kinase Inhibitors With Imidazopyridazine and Thiazolidinedione Structure Exert Potent Antitumor Activities

• Main Authors: Yuichi Sawaguchi (Author), Ryuta Yamazaki (Author), Yukiko Nishiyama (Author), Masayuki Mae (Author), Atsuhiro Abe (Author), Hiroyuki Nishiyama (Author), Fukiko Nishisaka (Author), Tatsuya Ibuki (Author), Toshio Sasai (Author), Takeshi Matsuzaki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pim kinases are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Here in this study, we investigated the preclinical profile of novel pan-Pim kinase inhibitors with imidazopyridazine and thiazolidinedione structure. Imida...