Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease

• Main Authors: Galina F. Makhaeva (Author), Nadezhda V. Kovaleva (Author), Elena V. Rudakova (Author), Natalia P. Boltneva (Author), Sofya V. Lushchekina (Author), Tatiana Yu Astakhova (Author), Elena N. Timokhina (Author), Olga G. Serebryakova (Author), Alexander V. Shchepochkin (Author), Maxim A. Averkov (Author), Irina A. Utepova (Author), Nadezhda S. Demina (Author), Eugene V. Radchenko (Author), Vladimir A. Palyulin (Author), Vladimir P. Fisenko (Author), Sergey O. Bachurin (Author), Oleg N. Chupakhin (Author), Valery N. Charushin (Author), Rudy J. Richardson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the inhibitory activities of novel 9-phosphoryl-9,10-dihydroacridines and 9-phosphorylacridines against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylesterase (CES). We also studied the abilities of the new compounds to interfere with the self-aggregation of...