Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity

• Main Authors: Xin Tang (Author), Chuanxi Wang (Author), Lei Wang (Author), Feifei Ren (Author), Runqiao Kuang (Author), Zhenhua Li (Author), Xue Han (Author), Yiming Chen (Author), Guodong Chen (Author), Xiuqing Wu (Author), Jie Liu (Author), Hengwen Yang (Author), Xingzhong Liu (Author), Chen Wang (Author), Hao Gao (Author), Zhinan Yin (Author)
• Format: Bog
• Udgivet: Elsevier, 2023-09-01T00:00:00Z.
• Fag: article
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Interleukin (IL)-17A, a pro-inflammatory cytokine, is a fundamental function in the onset and advancement of multiple immune diseases. To uncover the primary compounds with IL-17A inhibitory activity, a large-scale screening of the library of traditional Chinese medicine constituents and microbial s...