The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection.

• Main Authors: Elizabeth A Nelson (Author), Julie Dyall (Author), Thomas Hoenen (Author), Alyson B Barnes (Author), Huanying Zhou (Author), Janie Y Liang (Author), Julia Michelotti (Author), William H Dewey (Author), Lisa Evans DeWald (Author), Richard S Bennett (Author), Patrick J Morris (Author), Rajarshi Guha (Author), Carleen Klumpp-Thomas (Author), Crystal McKnight (Author), Yu-Chi Chen (Author), Xin Xu (Author), Amy Wang (Author), Emma Hughes (Author), Scott Martin (Author), Craig Thomas (Author), Peter B Jahrling (Author), Lisa E Hensley (Author), Gene G Olinger (Author), Judith M White (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) is a lipid kinase involved in endosome maturation that emerged from a haploid genetic screen as being required for Ebola virus (EBOV) infection. Here we analyzed the effects of apilimod, a PIKfyve inhibitor that was reported to be well tolerated in...