Implementation of Model-Based Dose Adjustment of Tobramycin in Adult Patients with Cystic Fibrosis

• Main Authors: Jérémy Reverchon (Author), Vianney Tuloup (Author), Romain Garreau (Author), Viviane Nave (Author), Sabine Cohen (Author), Philippe Reix (Author), Stéphane Durupt (Author), Raphaele Nove-Josserand (Author), Isabelle Durieu (Author), Quitterie Reynaud (Author), Laurent Bourguignon (Author), Sandrine Charles (Author), Sylvain Goutelle (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic drug monitoring (TDM) of tobramycin is widely performed in patients with cystic fibrosis (CF), but little is known about the value of model-informed precision dosing (MIPD) in this setting. We aim at reporting our experience with tobramycin MIPD in adult patients with CF. We analyzed dat...