Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential

• Main Authors: Omar Khoumeri (Author), Sébastien Hutter (Author), Nicolas Primas (Author), Caroline Castera-Ducros (Author), Sandra Carvalho (Author), Susan Wyllie (Author), Mohamed Lotfi Efrit (Author), Dimitri Fayolle (Author), Marc Since (Author), Patrice Vanelle (Author), Pierre Verhaeghe (Author), Nadine Azas (Author), Hussein El-Kashef (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 61 thiazolidine-2,4-diones bearing a styryl group at position 5 was synthesized in 2-5 steps and their structure was proved by elemental and spectral analyses. The compounds obtained were evaluated in vitro against the promastigote stage of the kinetoplastid parasite <i>Leishmania...