Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet

• Main Authors: Hayato Yanagihara (Author), Kentaro Ushijima (Author), Yusuke Arakawa (Author), Ken-ichi Aizawa (Author), Akio Fujimura (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although telmisartan, an angiotensin II receptor blocker (ARB), has an agonistic action for proliferator-activated receptor (PPAR)-γ in vitro, it remains to be determined whether telmisartan exerts such an action in vivo using a non-toxic dose (<5 mg/kg in rats). To address the issue, telmisartan...