Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses

• Main Authors: Thomas Ondet (Author), Pierre-François Roux (Author), Mario Monshouwer (Author), Georgios N. Stamatas (Author)
• 格式: 图书
• 出版: Elsevier, 2021-06-01T00:00:00Z.
• 主题: article
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EGFR inhibitors used in oncology therapy modify the keratinocyte differentiation processes, impairing proper skin barrier formation and leading to cutaneous adverse drug reactions. To uncover the molecular signatures associated with cutaneous adverse drug reactions, we applied phosphoproteomic and t...