Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity assessment

• Main Authors: Shuai Wang (Author), Yanqiu Wang (Author), Zhenzhen Li (Author), Ye Hong (Author), Zhaohui Wang (Author), Jiteng Fan (Author), Qiong Wang (Author), Yuanjie Ge (Author), Xiaofeng Zhao (Author), Guangcun Cheng (Author), Changyan Chen (Author), Yadan Wu (Author), Yayuan Fu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Precise measurement of the binding activity changes of therapeutic antibodies is important to determine the potential critical quality attributes (CQAs) in developability assessment at the early stage of antibody development. Here, we report a surface plasmon resonance (SPR)-based relative binding a...