Lactoferrin is a dynamic protein in human melioidosis and is a TLR4-dependent driver of TNF-α release in Burkholderia thailandensis infection in vitro.

• Main Authors: Shelton W Wright (Author), Lara Lovelace-Macon (Author), Deirdre Ducken (Author), Sarunporn Tandhavanant (Author), Prapit Teparrukkul (Author), Viriya Hantrakun (Author), Direk Limmathurotsakul (Author), Narisara Chantratita (Author), T Eoin West (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melioidosis is an often-severe tropical infection caused by Burkholderia pseudomallei (Bp) with high associated morbidity and mortality. Burkholderia thailandensis (Bt) is a closely related surrogate that does not require BSL-3 conditions for study. Lactoferrin is an iron-binding glycoprotein that c...