A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age‐dependent differences in absorption

• Main Authors: Eva J. Streekstra (Author), Márton Kiss (Author), Jeroen van denHeuvel (Author), Johan Nicolaï (Author), Petra van denBroek (Author), Sanne M. B. I. Botden (Author), Martijn W. J. Stommel (Author), Lara vanRijssel (Author), Anna‐Lena Ungell (Author), Evita van deSteeg (Author), Frans G. M. Russel (Author), Saskia N. deWildt (Author)
• Format: Book
• Published: Wiley, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Little is known about the impact of age on the processes governing human intestinal drug absorption. The Ussing chamber is a system to study drug transport across tissue barriers, but it has not been used to study drug absorption processes in children. This study aimed to explore the feasib...