Involvement of von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom.

• Main Authors: Camila Martos Thomazini (Author), Ana Teresa Azevedo Sachetto (Author), Cynthia Zaccanini de Albuquerque (Author), Vânia Gomes de Moura Mattaraia (Author), Ana Karina de Oliveira (Author), Solange Maria de Toledo Serrano (Author), Ivo Lebrun (Author), Katia Cristina Barbaro (Author), Marcelo Larami Santoro (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients bitten by snakes consistently manifest a bleeding tendency, in which thrombocytopenia, consumption coagulopathy, mucous bleeding, and, more rarely, thrombotic microangiopathy, are observed. Von Willebrand factor (VWF) is required for primary hemostasis, and some venom proteins, such as botr...