The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis

• Main Authors: Weijuan Shao (Author), Xiaoquan Xiong (Author), Wilfred Ip (Author), Fenghao Xu (Author), Zhuolun Song (Author), Kejing Zeng (Author), Marcela Hernandez (Author), Tao Liang (Author), Jianping Weng (Author), Herbert Gaisano (Author), M. Cristina Nostro (Author), Tianru Jin (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Disruption of TCF7L2 in mouse pancreatic β-cells has generated different outcomes in several investigations. Here we aim to clarify role of β-cell TCF7L2 and Wnt signaling using a functional-knockdown approach. Methods: Adenovirus-mediated dominant negative TCF7L2 (TCF7L2DN) expression wa...