The Glutaminase-1 Inhibitor [¹¹C-carbony]BPTES: Synthesis and Positron Emission Tomography Study in Mice

• Egile Nagusiak: Yiding Zhang (Egilea), Katsushi Kumata (Egilea), Lin Xie (Egilea), Yusuke Kurihara (Egilea), Masanao Ogawa (Egilea), Tomomi Kokufuta (Egilea), Nobuki Nengaki (Egilea), Ming-Rong Zhang (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a selective inhibitor of glutaminase-1 (GLS1), consequently inhibiting glutaminolysis. BPTES is known for its potent antitumor activity and plays a significant role in senescent cell removal. In this study, we synthesized [<s...