The Glutaminase-1 Inhibitor [¹¹C-carbony]BPTES: Synthesis and Positron Emission Tomography Study in Mice

• Main Authors: Yiding Zhang (Author), Katsushi Kumata (Author), Lin Xie (Author), Yusuke Kurihara (Author), Masanao Ogawa (Author), Tomomi Kokufuta (Author), Nobuki Nengaki (Author), Ming-Rong Zhang (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a selective inhibitor of glutaminase-1 (GLS1), consequently inhibiting glutaminolysis. BPTES is known for its potent antitumor activity and plays a significant role in senescent cell removal. In this study, we synthesized [<s...