Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity

• Главные авторы: Tarek S. Ibrahim (Автор), Mohamed M. Hawwas (Автор), Azizah M. Malebari (Автор), Ehab S. Taher (Автор), Abdelsattar M. Omar (Автор), Niamh M. O'Boyle (Автор), Eavan McLoughlin (Автор), Zakaria K. Abdel-Samii (Автор), Yaseen A. M. M. Elshaier (Автор)
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• Опубликовано: MDPI AG, 2020-11-01T00:00:00Z.
• Предметы: article
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A novel series of quinoline derivatives of combretastatin A-4 incorporating rigid hydrazone and a cyclic oxadiazole linkers were synthesized and have demonstrated potent tubulin polymerization inhibitory properties. Many of these novel derivatives have shown significant antiproliferative activities...