Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors

• Hoofdauteurs: Loghman Firoozpour (Auteur), Lixin Gao (Auteur), Setareh Moghimi (Auteur), Parvin Pasalar (Auteur), Jamshid Davoodi (Auteur), Ming-Wei Wang (Auteur), Zahra Rezaei (Auteur), Armin Dadgar (Auteur), Hoda Yahyavi (Auteur), Massoud Amanlou (Auteur), Alireza Foroumadi (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 position of isatin core exhibited better results c...