Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System
Central nervous system (CNS) drug disposition is dictated by a drug's physicochemical properties and its ability to permeate physiological barriers. The blood-brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter proteins influence drug disposition within...
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MDPI AG,
2014-03-01T00:00:00Z.
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