Proteasome Inhibitor YSY01A Abrogates Constitutive STAT3 Signaling via Down-regulation of Gp130 and JAK2 in Human A549 Lung Cancer Cells

• मुख्य लेखकों: Wei Huang (लेखक), Xia Yuan (लेखक), Ting Sun (लेखक), Shujie Fan (लेखक), Jun Wang (लेखक), Quan Zhou (लेखक), Wei Guo (लेखक), Fuxiang Ran (लेखक), Zemei Ge (लेखक), Huayu Yang (लेखक), Runtao Li (लेखक), Jingrong Cui (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Proteasome inhibition interfering with many cell signaling pathways has been extensively explored as a therapeutic strategy for cancers. Proteasome inhibitor YSY01A is a novel agent that has shown remarkable anti-tumor effects; however, its mechanisms of action are not fully understood. Here we repo...