Proteasome Inhibitor YSY01A Abrogates Constitutive STAT3 Signaling via Down-regulation of Gp130 and JAK2 in Human A549 Lung Cancer Cells

• Main Authors: Wei Huang (Author), Xia Yuan (Author), Ting Sun (Author), Shujie Fan (Author), Jun Wang (Author), Quan Zhou (Author), Wei Guo (Author), Fuxiang Ran (Author), Zemei Ge (Author), Huayu Yang (Author), Runtao Li (Author), Jingrong Cui (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proteasome inhibition interfering with many cell signaling pathways has been extensively explored as a therapeutic strategy for cancers. Proteasome inhibitor YSY01A is a novel agent that has shown remarkable anti-tumor effects; however, its mechanisms of action are not fully understood. Here we repo...