Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice

• Main Authors: Shuangxue Han (Author), Zhijun He (Author), Xia Hu (Author), Xiaoqian Li (Author), Kaixin Zheng (Author), Yingying Huang (Author), Peng Xiao (Author), Qingguo Xie (Author), Jiazuan Ni (Author), Qiong Liu (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reduction of the cerebral glucose metabolism is closely related to the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in Alzheimer's disease (AD); however, its underlying mechanism remains unclear. In this paper, ¹⁸F-flurodeoxyglucose positron emis...