Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats

• Glavni autori: T.M. Zaved Waise (Autor), Yu-Mi Lim (Autor), Zahra Danaei (Autor), Song-Yang Zhang (Autor), Tony K.T. Lam (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2021-02-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Objective: The mechanism of nutrient sensing in the upper small intestine (USI) and ileum that regulates glucose homeostasis remains elusive. Short-term high-fat (HF) feeding increases taurochenodeoxycholic acid (TCDCA; an agonist of farnesoid X receptor (FXR)) in the USI and ileum of rats, and the...