Telomere-related DNA damage response pathways in cancer therapy: prospective targets

• Main Authors: Liting Gu (Author), Mingdi Liu (Author), Yuning Zhang (Author), Honglan Zhou (Author), Yishu Wang (Author), Zhi-Xiang Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Maintaining the structural integrity of genomic chromosomal DNA is an essential role of cellular life and requires two important biological mechanisms: the DNA damage response (DDR) mechanism and telomere protection mechanism at chromosome ends. Because abnormalities in telomeres and cellular DDR re...