Lipidomic analysis of cancer cells cultivated at acidic pH reveals phospholipid fatty acids remodelling associated with transcriptional reprogramming

• Main Authors: Lorena Urbanelli (Author), Sandra Buratta (Author), Mariantonia Logozzi (Author), Nico Mitro (Author), Krizia Sagini (Author), Rossella Di Raimo (Author), Donatella Caruso (Author), Stefano Fais (Author), Carla Emiliani (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cells need to modulate the biosynthesis of membrane lipids and fatty acids to adapt themselves to an accelerated rate of cell division and survive into an extracellular environment characterised by a low pH. To gain insight this crucial survival process, we investigated the lipid composition...