Improved Tumor Control Following Radiosensitization with Ultrasound-Sensitive Oxygen Microbubbles and Tumor Mitochondrial Respiration Inhibitors in a Preclinical Model of Head and Neck Cancer

• Main Authors: Quezia Lacerda (Author), Hebah Falatah (Author), Ji-Bin Liu (Author), Corinne E. Wessner (Author), Brian Oeffinger (Author), Ankit Rochani (Author), Dennis B. Leeper (Author), Flemming Forsberg (Author), Joseph M. Curry (Author), Gagan Kaushal (Author), Scott W. Keith (Author), Patrick O'Kane (Author), Margaret A. Wheatley (Author), John R. Eisenbrey (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor hypoxia (oxygen deficiency) is a major contributor to radiotherapy resistance. Ultrasound-sensitive microbubbles containing oxygen have been explored as a mechanism for overcoming tumor hypoxia locally prior to radiotherapy. Previously, our group demonstrated the ability to encapsulate and del...