Assessing <i>Trans</i>-Inhibition of OATP1B1 and OATP1B3 by Calcineurin and/or PPIase Inhibitors and Global Identification of OATP1B1/3-Associated Proteins

• Main Authors: John T. Powell (Author), Ruhul Kayesh (Author), Alexandra Ballesteros-Perez (Author), Khondoker Alam (Author), Pascaline Niyonshuti (Author), Erik J. Soderblom (Author), Kai Ding (Author), Chao Xu (Author), Wei Yue (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are key determinants of drug-drug interactions (DDIs). Various drugs including the calcineurin inhibitor (CNI) cyclosporine A (CsA) exert preincubation-induced <i>trans</i>-inhibitory effects upon OATP1B1 and/or OATP1B3 (abbre...